Virulence profile: Laura Manuelidis.
نویسنده
چکیده
I grew up in Brooklyn during WWII and freely roamed the streets, spoke to a vast assortment of people, and slipped into the movies underage where they were playing concentration camps, the atom bomb and Superman. I alternately dreamed of becoming a classical dancer and a champion for the oppressed. The fabric of our abode was filled with diverse people, literature and architecture. The latter meant endless walks around construction sites before finally getting to swim at Coney Island. Little did I know that architecture would provide the cement and steel for my later appreciation of biologic structures from different perspectives.
منابع مشابه
Transmissible encephalopathy agents: virulence, geography and clockwork.
Transmissible spongiform encephalopathies (TSEs) are caused by infectious agents with stable virulence characteristics that are not encoded by the host. Agent-specific features of virulence include variable disease latency and tissue pathology in a given host, as well as the ability to spread to many species. Such cross-species infections contradict predictions based on the prion hypothesis. Re...
متن کاملA unifying perspective
The purpose of this perspective is to communicate several fundamental biologic features of TSE infections that may not be apparent to scientists who do not isolate and characterize infectious particles, or analyze different TSE agent-strains. At high multiplicity, TSE agents can induce pathological misfolding of host PrP into PrP-res amyloid. However, infection is not required for this conversi...
متن کاملInfectious particles, stress, and induced prion amyloids
Transmissible encephalopathies (TSEs) are believed by many to arise by spontaneous conversion of host prion protein (PrP) into an infectious amyloid (PrP-res, PrP (Sc) ) without nucleic acid. Many TSE agents reside in the environment, with infection controlled by public health measures. These include the disappearance of kuru with the cessation of ritual cannibalism, the dramatic reduction of e...
متن کاملThe kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt-Jakob disease and scrapie agents.
Human sporadic Creutzfeldt-Jakob disease (sCJD), endemic sheep scrapie, and epidemic bovine spongiform encephalopathy (BSE) are caused by a related group of infectious agents. The new U.K. BSE agent spread to many species, including humans, and clarifying the origin, specificity, virulence, and diversity of these agents is critical, particularly because infected humans do not develop disease fo...
متن کاملUnique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease.
Previous studies in Creutzfeldt-Jakob disease (CJD) have shown that myeloid cells in the periphery as well as derivative microglial cells in the brain are infectious. Microglia can show an activated phenotype before prion protein (PrP) pathology is detectable in brain, and isolated infectious microglia contain very little PrP. To find whether a set of inflammatory genes are significantly induce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Virulence
دوره 7 4 شماره
صفحات -
تاریخ انتشار 2016